Welcome to DrNashGlycoHealth
Scientifically proven natural iminosugars
Our Mission is to develop innovative improved pharmaceutical products to treat and cure serious illnesses utilising Glycobiology (sugar biology) and the Power of Plants. Our sources are natural plant extracts with health-promoting iminosugar content.
Science is key to our product range. Sugars or carbohydrates are vital to health in many ways and faults in sugar biochemistry occur in most diseases and in ageing. Iminosugars have the remarkable ability to correct many of these errors and restore a youthful balance.
There are many sugars used in the body for important functions and they offer exciting new opportunities for treating many diseases. For over 30 years our researchers have led the way in identifying natural plant iminosugars in herbal medicines and healthy foods and in determining how they work in promoting good health. Many modern fruit and vegetable varieties lack the iminosugars as they have been blindly bred-out in favour of shelf-life and appearance, etc. Most food supplement products based on extracts also lack the natural iminosugars in favour of coloured anti-oxidants which have usually no proven health benefit. We are now able to provide a unique product range based on our research that ensure the health-promoting natural iminosugars are present and measured.
What are Iminosugars?
The science of DrNashGlycoHealth is supported by our R&D company PhytoQuest Ltd with over 18 years of pharmaceutical discovery and development and over 200 refereed publications and patents. PhytoQuest are world leaders in the discovery of iminosugars and based on our research we believe them to be the elusive active components of many if not most herbal medicines (Nash et al., 2011). Iminosugars are natural, stable small carbohydrate analogues with the ring Oxygen replaced by Nitrogen. They are present in many clinically proven herbal medicines but rarely noticed in the past because they are difficult to detect and their effects on sugar biochemistry can be very subtle. They have a wide range of biological effects related to their ability to correct aberrations in sugar biochemistry; such aberrations occur in most diseases and iminosugars offer an exciting new way to control such diseases.
Why Plants Produce Iminosugars and How They Benefit Us
Plants use sunlight, carbon dioxide and water to produce sugars by photosynthesis. The sugars are the starting point for all molecules used for growth by plants and other organisms. Many plants protect these sugars by producing iminosugars that reduce the ability of other organisms to utilise the sugars efficiently. The iminosugars are present in almost all plants but have an enormous diversity of structures and biological activities. Sugars are important to human biochemistry not just for energy but also act as important signalling molecules on cells. The iminosugars are able to regulate sugar biochemical processes in animals in very specific ways. Some inhibit particular enzymes involved in sugar release from foods and the uptake into the blood stream. Others speed up the removal of sugars from the blood and improve control of blood glucose. We are particularly interested in new types of iminosugar that interact with sugar receptors and are effective at very low concentrations without inhibiting enzymes. A few rare compounds can correct defective immune responses.
The detection of iminosugars in plants has been very slow in the scientific literature because the analysis is difficult and most laboratories still do not see or measure them. They are little explored except by the researchers behind DrNashGlycoHealth. The importance of the iminosugars to good health is becoming clear. Many commercial health supplements from plants contain no iminosugars even if the source plant did. It is, therefore, important to ensure the extraction process allows iminosugars to be extracted otherwise the health benefits of the plant may be missing in the final product. Carbohydrates are crucially important to good health and iminosugars offer a unique natural way of regulating vital processes in the body using sugars.
All products from DrNashGlycoHealth carry the Iminosugar Certified logo. This means the iminosugars of the plant have been retained, measured and the product quality controlled for their concentration.
Iminosugar Science Network (ISN)
The science of iminosugars is a specialised area with few groups able to isolate and identify them in plants and microbial material. DrNashGlycoHealth has an advisory group (ISN) of the major researchers in the field of natural iminosugar isolation, biology and chemistry.
Dr Robert Nash
Professor Nash has a strong academic background in identification and bioactivity of herbal medicine novel active components with over 200 publications and patents. He started his career working at Kew Gardens working on anti-HIV agents that affected the surface sugars of viruses funded by the Medical Research Council. Robert went on to focus on the importance of sugars (‘the Glycome’) in cancer, immune responses and in many other disorders such as diabetes. He has a strong interest in improved disease prevention and complimentary medicine as well as new therapeutic agents. Years of work on medicinal plants and health-promoting foods by him and his team has identified many new iminosugar compounds helping to maintain a ‘glyco-balance’ and this work has led to the product range from DrNashGlycoHealth. New pharmaceutical compounds with novel targets are also being developed from this research. Robert was awarded the 1st Pierre Fabre Prize by the Phytochemical Society of Europe in 2001 for his work on iminosugars. The important issue for Robert is that the products or foods with health claims should work and an active compound and effect can be measured. There are many products available based on a traditional use that is often misleading or wrong and they are usually produced using processes that remove the active compounds or concentrate the wrong components. Many fruits and vegetables can be good for health but the modern varieties often have had the useful compounds removed in favour of, for example, good colour or shelf-life. Our products are checked using state-of-the-art in house instruments such as 500 MHz NMR, GCMS and LCMS and years of specialist know-how.
Nash, R.J., Kato, A., Yu, C-Y., Fleet, G.W.J. (2011) Iminosugars as therapeutic agents: recent advances and promising trends. Future Med. Chem. 3 (12): 1513-1521.